Synthesis of an artificial oral fluid matrix

1 Overview 1.1 A requirement has arisen for an artificial oral fluid to be synthesized. The artificial oral fluid will be bespoke, and must be synthesized according to the composition given in Table 1 of the Appendix. 1.2 Once synthesised the artificial oral fluid must then be used as a matrix for the preparation, validation and supply of a series of defined standard solutions which will be used in the development and evaluation of drug testing technologies. 1.3 Solutions with mixtures of controlled substances and...