Requirement for producer cell line for GMP viral vector packaging

NHSBT's Clinical Biotechnology Centre for the purpose of specifying the user requirement for HEK293-derived production cell line for the GMP-production of viral vectors and other recombinant proteins. The CBC has an MHRA licence for the manufacture of investigational medicinal gene therapy and recombinant protein products for use in clinical trials. In order to manufacture GMP-grade viral vectors and recombinant proteins for clinical trials, a GMP-qualified producer cell line is required.